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About CRUK Scotland Institute

Find out what we do, how we do it and why we do what we do.

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History

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Organisation Governance

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Scientific Advisory Board

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Sources of Funding

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Life in Glasgow

Find out about living and working in Glasgow and Scotland.

Our Research

Explore the science at CRUK Scotland Institute. Our research groups, the people who lead them, and how we work.

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Research Groups

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Vision and Strategy

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Research Integrity

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Grant Support

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Sustainability

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Use of Animals

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Annual Reports

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AI and Computational Biology

Advanced Technologies

State-of-the-art facilities and specialist expertise supporting research across the Institute.

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Technologies overview

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Beatson Advanced Imaging Resource

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Translational Molecular Imaging

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Flow Cytometry

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Mass Spectrometry

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Molecular Technology

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Deep Phenotyping

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Histology Service

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Transgenic Models of Cancer

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Transgenic Technology

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Data Science and Data Management

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Bioinformatics and Data Science

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Translational Research Collaborations Unit

Operations

The teams and services that keep the Institute running and support our research.

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Finance

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Information Services

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People and Culture

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Research Management

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Support Operations

Partners

The networks and organisations we work with to accelerate cancer research.

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Cancer Research UK Scotland Centre

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CRC Stars

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MRC National Mouse Genetics Network

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CRUK SI-UoG-Indonesia PhD Programme

Careers & Study

Jobs, studentships and opportunities for students at every stage at our world-renowned cancer research institute.

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Careers & Study Overview

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Current Vacancies

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Studentships

PhD opportunities at the Institute
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Studentship Vacancies

Open studentships to apply for
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CRUK SI-UoG-Indonesia PhD Programme

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John Paul Career Award

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Internships

For undergraduate and masters students
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High School Students

Events

The Institute hosts a range of seminars and meetings bringing international cancer researchers to Glasgow.

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All Events

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Glasgow Cancer Seminar Series

High Content Screening and Analysis

Beatson Advanced Imaging Resource

Our high content screening capability couples genetic and chemical high throughput screening with multiparametric phenotypic image analysis to support translational cancer research. We employ functional genomics (siRNA, shRNA, CRISPR) tools in both pooled and arrayed approaches to support target identification and target validation in multiple types of cancer. Our state-of-the-art image analysis capabilities, including a machine learning module, support identification of a suite of cellular phenotypes in both 2D and 3D environments.

Our 4 camera spinning disk confocal Revvity Opera Phenix High-Content Screening system is supported by a robotic plate-loading arm, and JANUS, Formulatrix Mantis and Wellmate liquid handling systems.

Back toBeatson Advanced Imaging Resource
Also at BAIRAdvanced light microscopy equipment

High-Content Screening Equipment

Opera Phenix

The Opera Phenix is a high-throughput confocal microscope primarily used for high-content screening and phenotype analysis. The system supports automated plate loading and image acquisition. The Opera Phenix is particularly advanced in 3D imaging of cells, organoids, spheroids and tissues. Coupled to Harmony/Image Analyst software, the Opera Phenix can generate large amounts of data suitable for bioinformatics and machine learning.

Perkin Elmer Janus MDT and Varispan

The Janus is an automated liquid handler with integrated robotics in a clean-air cabinet. Using the MDT fixed heads, 96 well and 384 well aspirate/dispense operations can be carried out. It is most commonly used to replicate plates, in high-throughput CRISPR, siRNA and compound screens. The Varispan platform can perform a versatile range of pre-programmed individual well operations, such as serial dilutions and cherry-picking of compounds from larger libraries.

Formulatrix Mantis

The Mantis is a liquid handling robot that uses microfluidics to dispense volumes from 0.1–5µl (and multiples), accurately and precisely with little waste. It is capable of complex, programmed, multiple liquid dispenses, and is commonly used to dispense cells in matrices, such as Matrigel, for 3D, high-throughput and high-content assays.