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About CRUK Scotland Institute

Find out what we do, how we do it and why we do what we do.

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Life in Glasgow

Find out about living and working in Glasgow and Scotland.

Our Research

Explore the science at CRUK Scotland Institute. Our research groups, the people who lead them, and how we work.

Operations

The teams and services that keep the Institute running and support our research.

Partners

The networks and organisations we work with to accelerate cancer research.

Careers & Study

Jobs, studentships and opportunities for students at every stage at our world-renowned cancer research institute.

Studentships

PhD opportunities at the Institute

Studentship Vacancies

Open studentships to apply for

Internships

For undergraduate and masters students

MRC National Mouse Genetics Network

The MRC National Mouse Genetics Network (NMGN) consists of eight disease-focused clusters pursuing distinctive, but complementary, challenge-led research and the Mary Lyon Centre at MRC Harwell acting as a central hub generating and robustly phenotyping strains, performing pre-clinical trials, and providing training.

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Years

Funding

Research Clusters

Pls

Mouse Models Created

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The Mary Lyon Centre

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Ageing

Time-resolved high-resolution map of age-associated phenotypic, cellular, and molecular changes in the mouse
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Cancer

Using complex state-of-the-art mouse models of cancer to improve the understanding and treatment of human cancer.
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Congenital Anomalies

Patient-led functional genomics – generation of precisely engineered mouse models of gene variants identified in patients and improved automated monitoring of early life.
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Degron Tagging

Precision control of protein dosage – our cluster aims to translate degron technologies into mouse models of human disease and share protocols with the community.
The Mary Lyon Centre Ageing Cancer Congenital Anomalies Degron Tagging Haem Microbiome Mitochondria MURIDAE

Hover a cluster below to see only its sites on the map.

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Haem

Developing new tools to revolutionise how we study normal and stressed haematopoiesis, and how we map and manipulate immune cell function for clinical benefit.
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Microbiome

Mouse models of barrier immunity dysfunction will allow investigation of the impact of the microbiome in human diseases involving barrier surfaces and new drug development.
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Mitochondria

An integrated phenotyping and mouse model generation platform for mitochondrial disease and dysfunction that aims to deliver new insights, therapies, and biomarkers.
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MURIDAE

MURIDAE (Modalities for Understanding, Recording and Integrating Data Across Early life) aims to improve the translatability of mouse models for neuropsychiatric and neurodevelopmental disease.

Key within these clusters are both experts in developing mouse genetic models, and translational and clinical scientists to provide a clear path to clinical translation. Furthermore, the clusters interact with each other to capitalise on the numerous opportunities there will be for cross-disease learning.

The CRUK Scotland Institute plays an essential role within the Network with Owen Sansom as Network Director and through the Cancer cluster, led by Karen Blyth. Find out more about the Network on our website:

nmgn.mrc.ukri.org