Molecular Imaging

As part of my role in the lab, I ensure the efficient running of the Translational Molecular Imaging facility and engage in multiple collaborative projects within the CRUK SI and further afield. My research interests surround the use of molecular imaging to non-invasively probe tumour evolution, and the biological validation of in vivo imaging signals. As part of Team CANCAN, a Cancer Cachexia Cancer Grand Challenge, I apply broad knowledge of molecular imaging and mouse models to use pre-clinical PET/MRI to probe systemic changes in metabolism during tumour development and cancer cachexia.

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My expertise lies in tumour biology and immunometabolism, with a focus on how cell-of-origin and immune metabolism shape cancer heterogeneity and therapeutic response. I use advanced techniques including preclinical PET imaging with [18F]FDG and [11C]acetate, radio-flow cytometry (RadioFlow), multi-omics, and spatial biology to study glucose and acetate utilization at tumour and single-cell levels. My work integrates molecular imaging and high-resolution metabolic profiling to uncover mechanisms driving cancer progression and identify therapeutic vulnerabilities.

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I am a medicinal chemist trained in radiochemistry. My postdoctoral research explores the metabolic drivers of cancer cachexia as part of the CANCAN Cancer Grand Challenge. I develop strategies to radiolabel endogenous amino acids and metabolites with carbon-11, create fluorine-18 radiolabelled metabolic analogues, and map how radiolabel position impacts image analysis.

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I am a cancer research scientist with expertise in in vivo oncology, genetically engineered mouse models, and tumour biology. As part of my role in the lab, I lead preclinical research on lung, colorectal, and liver cancers, including orthotopic tumour models. My work integrates advanced imaging (PET/MRI), molecular analysis, and transgenic mouse models to uncover disease mechanisms and identify therapeutic targets. I also coordinate and support molecular imaging studies across institutions, working closely with teams at the CRUK SI and the University of Glasgow.

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I am a radiochemist and PET imaging scientist specializing in tumour metabolism. My research explores metabolic heterogeneity in lung cancer and how nutrients like glucose and acetate are utilized across time and scales using multiplexed PET imaging, tracer techniques, and spatial biology. I integrate advanced molecular imaging with isotope tracing and mass spectrometry to uncover metabolic vulnerabilities. In my role, I also support the group’s daily operations, co-supervise students, and actively foster internal and external collaborations.

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I am a clinical radiation oncology and research fellow undertaking a PhD focused on the interplay between radiotherapy and cancer metabolism. My research investigates how metabolic pathways influence intrinsic radioresistance and how radiotherapy induces adaptive metabolic changes in cancer cells. I work primarily on lung cancer, studying how carnitine metabolism and fatty acid oxidation drive radioresistance. Using in vitro and in vivo models, I am developing drug–radiotherapy combinations to target these pathways, aiming to improve treatment response and overcome resistance.

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I am a PhD student in Cancer Sciences at the University of Glasgow, supported by the LPDP scholarship. I joined the CRUK Scotland Institute under the supervision of Dr. David Lewis and Dr. Helen Mulvana from the Centre for Medical and Industrial Ultrasonics (C-MIU) to investigate how different microbubble size fractions influence ultrasound imaging sensitivity and ultrasound-based perfusion imaging in preclinical breast cancer models. My goal is to identify optimal microbubble characteristics that enhance tumour perfusion assessment, improve diagnostic accuracy, and support treatment monitoring.

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I am a PhD student investigating how the immune system drives the profound metabolic disturbances characteristic of cancer cachexia. I focus on the systemic effects of cancer, specifically how tumours communicate with and reprogram distant tissues through immune-mediated mechanisms, leading to whole-body metabolic imbalance. By examining metabolic heterogeneity in lung and colorectal cancers, my work aims to identify the pathways linking immune activity to the development and progression of cachexia.

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I am a preclinical imaging specialist with19 years of experience, built upon a background in synthetic inorganic chemistry and radiochemistry. I lead and collaborate on research programmes that apply advanced imaging technologies, including total-body preclinical PET/CT and 7T MRI, to address complex biological questions. As part of my role, I am establishing a radiometal and radiobiology laboratory focused on developing 89Zr radiolabelling methods for biologically derived agents, such as antibodies and cells, enabling the long-term in vivo tracking of emerging biological therapies.

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I am a Postdoctoral Researcher in David’s Molecular Imaging Group, where my work focuses on the quantification of PET data using kinetic modelling. I completed my PhD at the University of Edinburgh, developing non-invasive quantification methods for dynamic PET data using Total-Body PET. My current research continues to centre on advancing PET quantification methods, with a particular interest in applying kinetic modelling to uncover biologically meaningful insights from imaging data. Prior to my PhD, I also studied Physics at the University of Edinburgh, where I developed a strong interest in interdisciplinary applied physics.

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