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ACRCelerate: Colorectal Cancer Stratified Medicine Network

The ACRCelerate Colorectal Cancer Stratified Medicine Network, led by Prof Owen Sansom, is a European-wide consortium of basic and clinical scientists at the forefront of CRC research.  It is a new and exciting venture jointly funded by CRUK, AIRC and FC AECC for 5 years (awarded December 2018).

Colorectal cancer (CRC) remains the second most common cause of cancer death. CRC presents an opportunity for precision medicine as it is common, has known driver molecular pathways and pre-treatment molecular stratification is achievable. Moreover, recent advances in sequencing technology and biological models have resulted in paradigm shifts in our understanding of CRC biology, but unfortunately have failed to significantly impact upon patient care.

The overarching aim of the ACRCelerate project is to de-risk future clinical trials by bridging the gap between tumour molecular signatures and targeted clinical trials.

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Our consortium offers a suite of state-of-the-art preclinical models (Genetically Engineered Mouse Models - GEMMs, organoids and xenografts) that recapitulate patient disease and allow the generation of robust and reproducible preclinical data.