Prof Seth Coffelt – Immune Cells and Metastasis


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Understanding how cancer spreads from its primary site of origin to distant organs is one of the major challenges in cancer research. What has become evident in recent years is that mutations in cancer cells are not sufficient to drive metastasis formation – cancer cells need assistance from surrounding healthy cells. Among these various healthy cells, immune cells have emerged as powerful instigators of metastasis formation but, at the same time, immune cells can also prevent cancer cells from spreading.

Our lab focuses on these dichotomous roles of immune cells and how tumours control immune cell behaviour. We study these concepts in the context of breast, pancreatic and colorectal cancers. We are particularly interested in γδ T cells, a rare population of T cells with properties that are distinct from conventional CD4 and CD8 T cells, as γδ T cells can be both pro-tumourigenic and anti-tumourigenic. Our ultimate goal is to understand how γδ T cells and other immune cells participate in the metastatic process and to develop new immunotherapies that counteract metastatic lesions.

Researchers discover key to 'supercharging' breast cancer treatment

Find out more about Seth's recent research in this article by STV News here.

Young Glasgow ovarian cancer survivor speaks out about life after the disease

Read the story from the Evening Times here.

Glasgow doctor reveals why he has taken on the city's fight against cancer

Read about Seth's background and move to Glasgow here.

University of Glasgow webpage

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